E2F1 activation is responsible for pituitary adenomas induced by HMGA2 gene overexpression

E2F1 activation is responsible for pituitary adenomas induced by HMGA2 gene overexpression

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Abstract The High Mobility Group protein HMGA2 is a nuclear architectural factor that plays a critical role in a wide range of biological processes including regulation of gene expression, embryogenesis and neoplastic transformation.Several studies are trying to Gut Microbiota and Metabolome Description of Antibiotic-Treated Neonates From Parturients With Intrauterine Infection identify the mechanisms by which HMGA2 protein is involved in each of these activities, and only recently some new significant insights are emerging from the study of transgenic and knock-out mice.Overexpression of HMGA2 gene leads to the onset of prolactin and GH-hormone induced pituitary adenomas in mice, suggesting a critical role of this protein in pituitary tumorigenesis.This was also confirmed in the human pathology by the finding that HMGA2 amplification and/or overexpression is present in human prolactinomas.

This review focuses on recent data that explain the mechanism by which HMGA2 induces the development of A new species and new records of Oxysarcodexia Townsend (Diptera: Sarcophagidae) from Brazil pituitary adenomas in mice.This mechanism entails the activation of the E2F1 protein by the HMGA2-mediated displacement of HDAC1 from pRB protein.